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KMID : 0361120090230020149
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Korean Journal of Transplantation
2009 Volume.23 No. 2 p.149 ~ p.153
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Comparison of New Onset Diabetes according to the Time of Onset in Kidney Transplant Recipients
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Yoon Kyu-Jong
Park Jun-Ho
Kim Doo-Jin
Park Sung-Gil
Lee Jeong-Hoon
Kim Joo-Seop
Hyun Suk-Ja
Lee Sam-Uel
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Abstract
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Background: New onset diabetes is a common complication after kidney transplantation. However, the clinical course of post-transplant diabetes mellitus (PTDM) remains unclear. The aim of the present study is to analyze the natural courses and risk factors of PTDM according to the time of onset.
Methods: A total of 216 consecutive kidney transplant recipients were enrolled and patient medical records were investigated retrospectively. PTDM was defined as glucose ≥126mg without previous diabetic history. Patients were classified according to the onset (12 months): early PTDM (E-PTDM) and late PTDM (L-PTDM).
Results: PTDM was observed in 34 (17.4%) patients. The number of E-PTDM and L-PTDM patients was 17 and 17. Compared with normoglycemic patients, the PTDM group was older and showed higher pre-transplant HbA1c level. The use of tacrolimus was associated with the development of E-PTDM (OR=4.87, 1.71∼13.8 in 95% CI) but not L-PTDM (OR=0.34, 0.04∼2.70 in 95% CI)
Conclusions: The development of E-PTDM and L-PTDM may have different risk factors. It will be important to choose different therapeutic strategy according to the onset of PTDM.
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KEYWORD
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Renal transplantation, Post-transplantation diabetes mellitus, Risk factor
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